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Date : 2013-12-16
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Genome Stability DNA Repair and Recombination ~ Genome Stability DNA Repair and Recombination is targeted for a more advanced audience as it assumes a basic understanding of DNA replication and meiosis Senior undergraduate students or graduate students would benefit from this text to improve their molecular understanding of recombination
Genome Stability DNA Repair and Recombination James ~ Genome Stability DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination most notably the repair of chromosomal breaks The text presents a definitive history of the evolution of molecular models of DNA repair emphasizing current research The book introduces the central players in recombination
Genome Stability DNA Repair and Recombination Taylor ~ Genome Stability DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination most notably the repair of chromosomal breaks The text presents a definitive history of the evolution of molecular models of DNA repair emphasizing current research The book introduces the central players in recombination
DNA replication recombination and repair ~ Lorraine Symington Columbia University works with budding yeast to study the genetic mechanism of homologous recombination that is mediated by the RAD52 gene group and the involvement of recombination in DNA doublestrand break repair the maintenance of genetic stability and meiosis
Homologous recombination in DNA repair and DNA damage ~ Keywords DNA repair doublestrand breaks genome stability homologous recombination interstrand crosslinks stalled replication forks Introduction DNA damage is a fact of life as a consequence of endogenous sources and processes as well as exogenous sources 1
Coordination of DNA Replication and Recombination ~ Across the evolutionary spectrum living organisms depend on highfidelity DNA replication and recombination mechanisms to maintain genome stability and thus to avoid mutation and disease The repair of severe lesions in the DNA such as doublestrand breaks or stalled replication forks requires the coordinated activities of both the homologous recombination and DNA replication machineries
Roles of RECQ helicases in recombination based DNA repair ~ One such group of proteins that is actively involved in genome surveillance is the RecQ helicase family These proteins are highly conserved DNA helicases which have diverse roles in multiple DNA metabolic processes such as DNA replication recombination and DNA repair
BRCA2 Homolog Required for Proficiency in DNA Repair ~ Three primary conclusions can be drawn from the present work First a BRCA2 related gene has been discovered in a simple genetically amenable lower eukaryote Second the gene BRH2 is required for proficiency in repair and recombination and serves in maintaining genome stability in mitosis and meiosis
RPA and RAD51 fork reversal fork protection and genome ~ Replication protein A RPA and RAD51 are DNAbinding proteins that help maintain genome stability during DNA replication These proteins regulate nucleases helicases DNA translocases and signaling proteins to control replication repair recombination and the DNA damage response
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